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Electron Microscopes: In 1931 Max Knoll and Ernst Ruska invented the first electron microscope that blasted past the optical limitations of the light. Physics dictates that light microscopes are limited by the physics of light to 500x or 1000x magnification and a resolution of 0.2 micrometers. The microscope was one of the most significant inventions of the Scientific Revolution, opening up completely new and miniaturised worlds. The first microscopes were invented in the first quarter of... One moment, please...Please wait while your request is being verified... Learn who discovered microscope and how it changed the world of science and medicine. Explore the history and evolution of microscopes from the 16th century to the present day.