RUTHLESS meaning : 1. not thinking or worrying about any pain caused to others; cruel: 2. not thinking or worrying…. Learn more. Definition of ruthless in the Definitions.net dictionary. Meaning of ruthless . What does ruthless mean ? Information and translations of ruthless in the most comprehensive dictionary definitions resource on the web. Ruthless means not caring about the pain or suffering of others, or determined to succeed without mercy. Learn more about the word, its synonyms, antonyms, and usage in sentences. Ruthless means having no mercy or pity, or lacking scruples or principles. Find the origin, usage, and translations of ruthless in English and Spanish dictionaries.