2 meanings : 1. extremely unpleasant 2. obsolete exposed to harm, injury, etc.... Click for more definitions. Obnoxious definition : Very annoying or objectionable; offensive or odious. Obnoxious means very unpleasant or rude, or very unpleasant or offensive. Learn how to pronounce it, see examples and synonyms, and find translations in other languages. Definition of obnoxious adjective in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.