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Miosis is the excessive constriction of your pupil, which can be a sign of various diseases or conditions affecting your brain or nervous system. Learn about the possible causes, symptoms, diagnosis, and treatment of miosis, and when to see a doctor. Mydriasis is a condition where the pupils are dilated, allowing more light to enter the eye, which can be caused by low light conditions, certain medications, or neurological damage. Miosis, on the other hand, involves the constriction of the pupils, decreasing the amount of light that enters the eye, and is often a response to bright light, certain drugs, or as a part of the normal aging process. Miosis occurs naturally when doing close work or when stimulated by light. Note: also spelt myosis. See corneal reflex; pupil light reflex; baring of the blind spot; Horner's syndrome. Miosis of the eye is a condition characterized by the abnormal constriction of the pupil. This phenomenon involves a reduction in the size of the pupil.