Discover the latest breakthroughs in migraine treatment for 2025, including CGRP inhibitors, AI-powered personalized plans, wearable neuroregulators, and mRNA-based therapies. Learn expert ... There's a wide range of migraine treatment options including prescription drugs, over-the-counter painkillers, devices, natural remedies, and more. Migraine headaches can be treated with two drug approaches: abortive and preventive. Learn more from WebMD about how each type works to curb or shorten migraines. There are many migraine treatments available, from preventive and abortive medications to supplements and home remedies to relieve the pain. Learn more.