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The Mentzer index is a ratio of MCV and RBC count that helps distinguish iron deficiency anemia from beta thalassemia trait. Learn how it is calculated, interpreted and used in clinical practice. Use this tool to calculate the Mentzer Index , a haematological index that helps differentiate between iron deficiency anemia and beta thalassemia. Learn the formula, the purpose, and the references of this index . Mentzer Index is a hematological tool used to help differentiate between iron deficiency anemia (IDA) and thalassemia trait (TT) when a patient presents with microcytic hypochromic anemia. Use this Mentzer index calculator to determine, if anemia is more probably due to iron deficiency or thalassemia.