Lube definition: lubricant.. See examples of LUBE used in a sentence. Lube is a slippery substance used to reduce friction between surfaces , often applied to machinery, engines, or body parts for smoother movement. It can also refer to personal lubricants for comfort during intimate activities. To lubricate (a car's joints, for example). n. A lubricant , such as one applied to machinery: silicone lube . [Shortening and alteration of lubricant and lubricate .] American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. The meaning of LUBE is lubricant. How to use lube in a sentence.

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