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Creatine is a compound that comes from three amino acids. Creatine is found mostly in your body's muscles as well as in the brain. Most people get creatine through seafood and red meat — though at levels far below those found in synthetically made creatine supplements. The body's liver, pancreas and kidneys also can make about 1 gram of creatine per day. People use creatine to improve athletic performance and increase muscle mass, but the potential benefits of creatine as a health supplement are vast. Learn more here. Creatine monohydrate is a popular supplement primarily taken to enhance muscle strength and power. However, it may provide other health benefits. Creatine Creatine supplies energy to your muscles. Many people take creatine supplements to build strength and promote brain health. Creatine supplements are safe for most people to take, but you should first talk to a healthcare provider to ensure they’re right for you.