Avian metapneumovirus has been divided into four subgroups—A, B, C and D. Bayesian estimates suggest that human metapneumovirus emerged between 1875 and 1889 and diverged from avian metapneumovirus around 1800. Footnote: Schematic representation of the human metapneumovirus life cycle. After attachment of the virion to the plasma membrane, the viral and plasma membranes fuse, resulting in uncoating of the virion and release of the RNP (containing the negative-sense viral RNA) into the cytoplasm. After primary transcription, the genome is replicated to produce the antigenome. The antigenome is used to synthesize genomic RNA, which is used to produce additional antigenomes for incorporation into ... Human metapneumovirus (hMPV) is a respiratory virus, first reported the year 2001. Since then, it has been described as one of the main etiological agents that causes acute lower respiratory tract infections (ALRTIs), which is characterized by symptoms such as bronchiolitis, wheezing and coughing. Human Metapneumovirus-Life Cycle No pulmonary inflammation Panda S. et al. Int J of Infect Dis 2014, 25:45-52 Antiviral TLR7 > IRF 3/7 > IFNs
