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The difference between efficacy and efficiency is their focus. Efficacy focuses on effectiveness and it measures whether the goal is achieved, whereas efficiency focuses on optimization and it achieves the goal with minimal waste. The noun ' efficacy ' has its etymological origins in Latin. It is derived from the Latin word 'efficacia,' which is formed from 'efficax,' meaning 'effective' or 'powerful,' and the suffix '-ia,' indicating a quality or state. In its original Latin sense, ' efficacy ' conveyed the idea of being effective or possessing the power to produce desired results. Over time, it evolved to describe the ability or capacity of something, typically a method, treatment, or intervention, to produce the ... The meaning of EFFICACY is the power to produce an effect. How to use efficacy in a sentence. efficacy definition : ability to produce a desired result. Check meanings, examples, usage tips, pronunciation, domains, and related words. Discover expressions like "self- efficacy ", "luminous efficacy ", "prove the efficacy ".