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Depression is a common illness characterized by persistent sadness and a loss of interest in activities that one normally enjoys, accompanied by an inability to carry out daily activities, for at least two weeks. Depression , in psychology, is a mood or emotional state marked by feelings of low self-worth or guilt and a reduced ability to enjoy life. Depression differs from simple grief or mourning and can be classified into different types. Learn more about the causes, symptoms, types, and treatments for depression . Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression , it affects how you feel, think and behave and can lead to a variety of emotional and physical problems. You may have trouble doing normal day-to-day activities, and sometimes you may feel as if life isn't worth living. Depression is a common mental health condition that involves low mood and other symptoms. Learn about the types, causes, treatment options, and more.