Know more about what is Combiflam ? what are the side effects and its uses. Combiflam is a combination of paracetamol and ibuprofen. Used for treatment of Headache, Migraine, Dental pain, Menstrual pain, Joint pain, and Arthritis. Combiflam Tablet is a painkiller that contains ibuprofen and paracetamol. It is used to treat inflammation and pain caused by various conditions, but it has some contraindications and interactions. Learn more about its dosage, substitutes, price and FAQs. Combiflam Tablet is used to treat mild to moderate pain, inflammation, and fever. It is effective for conditions such as headaches, muscle aches, menstrual cramps, toothaches, and joint pain. It can also help relieve backache, rheumatic pain, sore throat, and post-surgical discomfort. Combiflam is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation ...